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KMID : 0391419930030020204
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Korean Journal of Lipidology
1993 Volume.3 No. 2 p.204 ~ p.214
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Serum Lipid Profiles in Korean Postmenopausal Women and Their Cardiovascular risk Factors
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Abstract
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Although coronary artery disease is often viewed as a male affliction, women are not immune. As the population ages, the risk of coronary artery disease in postmenopausal women continues to grow as a public health concern. To assess the
prevalence
of
hyperlipidemia and to find out possible cardiovascular risk factors associated with increased insulin resistance, we analyzed the metabolic data of 300 nondiabetic postmenopausal women, selected representatively from Yonchon Cardiovascular Risk
Cohort.
The prevalence of hypercholesterolemia(serum cholesterol>220mg/dl) was as low 5.1%, while that of hypertriglyceridemia(serum triglceride>250mg/dl) was 11.7%. The serum cholesterol and triglyceride levels increased as body mass indices and waist
hip
ratio increased. The stepwise forward regression analysis using apo B lipoproteins, serum triglyceride concentrations, HDL cholesterol concenrtrations, systolic blood pressure, daily fat intake, body mass indices, and serum insulin levels as
independent
variables showed that only the mass indices were associated with serum insulin levels, which represented the level of insulin resistance.
From these results, we could postulate that although the prevalence of hypercholesterolemia was lower than in Caucasians, the cardiovascular risk was rather high, when we consider the fact that those with high serum triglyceride concentrations,
combined
with low serum HDL cholesterol concentrations had the increased risk of atherosclerosis by way of deepening the level of insulin resistance. That is to say that as they get more fat, they can get more serum insulin level, which ultimately leads
to
the
increased cardiovascular risk.
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KEYWORD
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